RNA Talking Back

definition. The hMre11 function was first detected in by specific nucleotide, on RNA transcription products, should be of interest to many. More so because, while a two-hybrid screen for proteins that interact with the replication factor DNA ligase I, but this putative interac-we can categorize RNA editing events, we cannot yet predict from species to species which genes or sites tion now is believed to have been spurious. The hRAD50 gene was found in a survey of cDNAs from a region within genes will be subject to editing. In some cases, we still do not know what informs the editing machinery of chromosome 5q that apparently encoded a tumor suppressor gene for myeloid leukemia, but hRAD50 was to choose a particular target. One aspect of RNA editing that comes shining through in the book of the same subsequently ruled out as a candidate tumor suppressor. Further studies of these proteins, and comparisons title is the diversity of expression of this form of RNA regulation/processing. RNA editing occurs in plants, with the yeast system, revealed their crucial roles as recombination factors. This is a good illustration of the mammals, and protozoa, and is exercised upon tRNA, rRNA, and mRNA transcripts. If this is not enough to fact that initially unpromising chance discoveries in hypothesis driven research may still produce results of tease the uninitiated, the mechanistic legerdemain exhibited in the course of performing this task should great significance. The unraveling of the third component of this recombination complex, Xrs2/p95, resulted equally astound. in its identification as the target of mutations that cause " Come, listen, my men, while I tell you again Nijmegen breakage syndrome, a serious inherited disor-The five unmistakable marks der associated with chromosome instability, increased By which you may know, wheresoever you go, cancer risk, and hypersensitivity to ionizing radiation. The warranted genuine Snarks " Additional articles include two extensive chapters on The Hunting of the Snark: An Agony in Eight Fits, the repair in human cells of abasic sites, the most com-by Lewis Carroll mon of all DNA lesions, and a detailed account with over 300 references of the role of DNA repair processes in As stated above, RNA editing is a process for intro-the generation of immune diversity. The latter chapter ducing nucleotide changes into RNA transcription prod-does not include the latest breakthroughs in the field, ucts that are not templated in their respective genomes such …